HER2 activation results in β-catenin-dependent changes in pulmonary epithelial permeability
نویسندگان
چکیده
منابع مشابه
HER2 activation results in β-catenin-dependent changes in pulmonary epithelial permeability.
The receptor tyrosine kinase human epidermal growth factor receptor-2 (HER2) is known to regulate pulmonary epithelial barrier function; however, the mechanisms behind this effect remain unidentified. We hypothesized that HER2 signaling alters the epithelial barrier through an interaction with the adherens junction (AJ) protein β-catenin, leading to dissolution of the AJ. In quiescent pulmonary...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2015
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00237.2014